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Transformation of lung adenocarcinoma to small cell lung carcinoma in the setting of tyrosine kinase inhibitor therapy: Cytological approach of a clinically challenging phenomenon
Author(s) -
El Hussein Siba,
Khader Samer N
Publication year - 2019
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.24193
Subject(s) - medicine , cytopathology , adenocarcinoma , lung , transformation (genetics) , tyrosine kinase inhibitor , pathology , neoplastic transformation , malignant transformation , lung cancer , carcinoma , small cell carcinoma , pathological , adenocarcinoma of the lung , tyrosine kinase , cancer , cytology , carcinogenesis , biology , receptor , biochemistry , gene
Lung adenocarcinoma transformation into small cell lung carcinoma is a well‐established phenomenon. Several reports and studies have been published, describing the clinical and pathological clues to detect this transformation. This article will discuss the cytological aspect of this entity, highlighting pertinent features, to bring more attention to the existence of this transformation into the cytopathology practice.