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Cytological features in eight patients with ALK ‐rearranged lung cancer
Author(s) -
Kuroda Naoto,
Ohara Masahiko,
Wada Yukari,
Yasuoka Kaori,
Mizuno Keiko,
Yorita Kenji,
Obayashi Chiho,
Takeuchi Kengo
Publication year - 2018
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23879
Subject(s) - nucleolus , lung cancer , pathology , signet ring cell , chromatin , extracellular , medicine , mucin , cancer , adenocarcinoma , biology , dna , microbiology and biotechnology , genetics , cytoplasm
Background ALK ‐rearranged lung cancer has been recently identified. Although signet‐ring cell morphology and mucinous cribriform pattern are considered to be characteristic of ALK ‐rearranged lung cancer. Some studies have also suggested cytological features. Methods This study investigated cytological features of ALK ‐rearranged lung cancer in eight patients. Results Cytologically, the tumor cell group varied from isolated to large clusters. Small nucleoli, fine granular to vesicular chromatin, and nuclear groove were observed in all patients. Furthermore, extracellular and intracellular mucin and signet‐ring cells were identified in five patients. Conclusion This study demonstrated that the presence of extracellular and intracellular mucin, signet‐ring cells, small nucleoli, fine granular to vesicular chromatin, and nuclear groove in cytological samples may be a diagnostic clue for ALK ‐rearranged lung cancer.