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Cyto‐histological correlation of X p11.2 translocation/ TFE 3 gene fusion associated renal cell carcinoma: Report of a case with review of literature
Author(s) -
Manucha Varsha,
Sessums Mary T.,
Lewin Jack,
Akhtar Israh
Publication year - 2018
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23839
Subject(s) - tfe3 , renal cell carcinoma , chromosomal translocation , psammoma body , medicine , pathology , clear cell , hyaline , gene , biology , immunohistochemistry , gene expression , genetics , promoter
The MiT family translocation renal cell carcinomas (RCCs) are relatively rare in comparison to the conventional RCC. The cytologic features overlap with conventional clear cell RCC and papillary RCCs, thereby making the diagnosis extremely challenging. Here, we describe a case of TFE3 translocation associated RCC in a 58‐year‐old patient, with emphasis on cytomorphologic features and clues toward this diagnostic entity. Correlating the cytohistologic findings and review of touch imprints revealed that presence of hyaline nodules resembling leisegang rings and psammoma bodies in cytologic smears from kidney tumors serve as an important clue in raising a suspicion for the diagnosis of MiT family translocation RCCs.