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The clinical performance of computer‐assisted liquid‐based cytology, primary hrHPV screening, and cotesting at a Turkish Tertiary Care Hospital
Author(s) -
Kir Gozde,
Seneldir Hatice,
Cosan Sarbay Billur
Publication year - 2018
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23836
Subject(s) - medicine , cytology , liquid based cytology , gynecology , biopsy , obstetrics , radiology , cancer , cervical cancer , pathology
Background We aimed to compare the performance of computer‐assisted liquid‐based cytology, primary high‐risk human papillomavirus (hrHPV) screening, and cytology‐hrHPV cotesting with regards to the detection rate of cervical cancer precursor lesions. Methods A total of 22,653 computer‐assisted liquid‐based cytology specimens interpreted between 2013 and 2015 were included in the study. We compared the false‐negative rates and sensitivities for computer‐assisted liquid‐based cytology, primary hrHPV screening and cytology‐hrHPV cotesting among women with normal and abnormal cytologies. Among 1,748 women who had undergone cotesting, 249 underwent follow‐up biopsies. Results For detecting biopsy‐confirmed high‐grade lesions, the sensitivities of using hrHPV, Pap tests, and cytology‐hrHPV cotesting were 90.67%, 88%, and 98.67%, respectively, while the false‐negative rates for hrHPV and Pap tests were 9.3% and 12%, respectively. The false negative rate for cotesting was only 1.3%. Conclusion Based on the significantly high sensitivity and lower false‐negative rates achieved, we conclude that the combination of cytologic screening with hrHPV testing is the best preferred strategy for detection of cervical precursor lesions in our country's conditions.