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Diagnosis of pediatric neuroblastoma by urine cytology: A case report
Author(s) -
Nishikawa Shiori,
Noguchi Hiroshi,
Tokumitsu Takako,
Ohno Akinobu,
MoriguchiGoto Sayaka,
Maekawa Kazunari,
Asada Yujiro,
Moritake Hiroshi,
Kinoshita Mariko,
Yamada Ai,
Takamura Kazunari,
Sato Yuichiro
Publication year - 2018
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23831
Subject(s) - urine cytology , cytology , medicine , pathology , neuroblastoma , chromogranin a , ganglioneuroblastoma , urine , biopsy , synaptophysin , urinary system , urology , cystoscopy , ganglioneuroma , immunohistochemistry , biology , genetics , cell culture
Neuroblastomas are embryonal tumors arising from the neuronal crest cells of the synaptic nervous system. Findings from aspiration cytology have been reported, but there have been no reports of urine cytology findings. Here, we report a case of pediatric neuroblastoma characterized by urine cytology. A 2‐year‐old boy presented with abdominal pain, nausea, and loss of appetite. Computed tomography revealed a large tumor in the left suprarenal region with massive infiltration into the kidney. Urinary cytology showed highly cellular clusters composed of small, round, atypical cells with little cytoplasm and high nuclear/cytoplasmic ratio; nuclear molding was also noted in some places. Immunocytochemical staining was positive for synaptophysin and chromogranin A, and neuroblastoma was suggested by urine cytology. A biopsy of the left adrenal tumor later confirmed a diagnosis of poorly differentiated neuroblastoma. Urine cytology may be useful for rapid diagnosis and management of similar cases.