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Adamantinoma‐like Ewing sarcoma of the parotid gland: Cytopathologic findings and differential diagnosis
Author(s) -
Lilo Mohammed T,
Bishop Justin A,
Olson Matthew T,
Ali Syed Z
Publication year - 2018
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23829
Subject(s) - adamantinoma , cd99 , sarcoma , medicine , pathology , parotid gland , differential diagnosis , primitive neuroectodermal tumor , fine needle aspiration , ewing's sarcoma , neck mass , epithelioid sarcoma , anatomy , immunohistochemistry , biopsy , ameloblastoma , maxilla , vimentin
Adamantinoma‐like Ewing sarcoma (AES) is a rare variant of Ewing sarcoma family of tumors (EFTs), primarily affecting bone and soft tissue. AES has mixed features of Ewing sarcoma (ES)/primitive neuroectodermal tumor (PNET) and adamantinoma with a complex immunoprofile and EWSR1 gene rearrangements. Herein, we report a 72‐year‐old male who presented with left parotid mass, right neck mass and thyroid nodules. Fine needle aspiration of the left parotid mass displayed nests of monotonous epithelioid cells with basaloid features in a background of small round blue cells and lymphocytes. AES can involve head and neck region and is characterized by groups of primitive small round blue cells admixed with groups of epithelioid cells with amphophilic cytoplasm and focal squamous differentiation. The proportion of these components can be variable, creating diagnostic challenges, particularly in unusual anatomic sites such as the parotid gland. However, when additional material is available, CD99 and/or FLI1 immunostains need to be included for diagnostic confirmation.