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Imprint cytology of clear cell sarcoma‐like tumor of the gastrointestinal tract in the small intestine: A case report
Author(s) -
Kato Takashi,
Ichihara Shin,
Gotoda Hiroko,
Muraoka Shunji,
Kubo Terufumi,
Sugita Shintaro,
Hasegawa Tadashi
Publication year - 2017
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23786
Subject(s) - pathology , cytokeratin , vimentin , eosinophilic , gastrointestinal tract , medicine , cytopathology , sarcoma , cytology , fluorescence in situ hybridization , biology , immunohistochemistry , gene , biochemistry , chromosome
Clear cell sarcoma‐like tumor of the gastrointestinal tract (CCSLGT) is an extremely rare malignant neoplasm in the digestive tract. Its cytomorphologic features have never previously been reported. Here, we describe a case of CCSLGT, including its cytologic examination findings. A 47‐year‐old woman presented with a mass in the small intestine, which was resected and sent for imprint cytology. Imprint smears revealed tumor cells with light eosinophilic or clear cytoplasm in a necrotic background. Many of the tumor cells were arranged in a perivascular growth with a pseudopapillary formation, and there were some non‐neoplastic osteoclast‐like giant cells. Histological examination revealed solid nests and a pseudopapillary pattern of the tumor cells with clear or pale eosinophilic cytoplasm and large nuclei with small nucleoli. Immunohistochemistry showed positive for vimentin, S‐100, and SOX‐10, and negative for SMA, c‐KIT, cytokeratin, HMB‐45, and MelanA. The EWSR1 gene split signal was detected by reverse transcriptase fluorescence in situ hybridization, and EWSR1–CREB1 gene fusion was indicated by reverse transcriptase polymerase chain reaction analysis. From these findings, we diagnosed the tumor as CCSLGT. To best of our knowledge, this is the first description of the imprint cytology features of CCSLGT.