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Lung cancer samples preserved in liquid medium: One step beyond cytology
Author(s) -
Mariano Vânia Sammartino,
Leal Letícia Ferro,
Pastrez Paula Roberta Aguiar,
Silva Estela Maria,
Reis Rui Manuel,
LongattoFilho Adhemar
Publication year - 2017
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23743
Subject(s) - medicine , lung cancer , pathological , liquid biopsy , pathology , liquid based cytology , lung , cytology , cancer , molecular diagnostics , sampling (signal processing) , biopsy , lung cancer screening , oncology , bioinformatics , cervical cancer , filter (signal processing) , computer science , computer vision , biology
Lung cancer is one of the most common cancer types in men and women worldwide with a high mortality rate. World Health Organization (WHO) classification has accepted biopsy as the primary sample for lung cancer diagnosis, pathological classification and molecular testing for management of patients, yet, the use of alternative sampling procedures is highly encouraged. Bronchial cytological samples require a less invasive collection technique and may be suitable for pathological and molecular analysis and storage in liquid medium. Furthermore, the molecular analysis of bronchial cytological samples allows the detection of molecular biomarkers, which may be useful for the selection of molecular targeted therapies. Thus, the purpose of this review is to describe the usefulness of bronchial cytological samples preserved in liquid medium from lung cancer patients for pathological diagnosis and molecular investigation.