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Metastatic thyroid carcinoma presenting as malignant pleural effusion: A cytologic review of 5 cases
Author(s) -
Vyas Monika,
Harigopal Malini
Publication year - 2016
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23547
Subject(s) - medicine , thyroid , thyroid carcinoma , pleural effusion , pathology , thyroglobulin , carcinoma , context (archaeology) , thyroid cancer , metastatic carcinoma , malignant pleural effusion , lung cancer , paleontology , biology
Malignant pleural effusion can be a manifestation of many malignancies. Involvement of pleural fluid by metatstatic thyroid carcinoma, though reported, is relatively rare. We present 5 cases of metastatic thyroid carcinoma involving the pleural fluid. The diagnosis of thyroid carcinoma in pleural fluid can be particularly challenging as thyroid transcription factor −1 (TTF‐1) which is a marker for carcinoma of thyroid origin is also positive in lung adenocarcinomas (which are more frequently associated with pleural effusions) and thyroglobulin (TG) can often be negative in poorly differentiated/analplastic thyroid carcinomas. In our experience, PAX8 is a particularly useful marker in making the distinction. The diagnosis of metastatic thyroid carcinoma in pleural fluid can be challenging and knowledge of the clinical context and supporting immunohistochemical stains is essential for making the right diagnosis. Diagn. Cytopathol. 2016;44:1085–1089. © 2016 Wiley Periodicals, Inc.