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Glandular epithelial abnormalities on thinprep ® pap tests: Clinical and cytohistologic correlation
Author(s) -
Selvaggi Suzanne M.
Publication year - 2016
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23452
Subject(s) - medicine , cytopathology , cytology , adenocarcinoma , pathology , asymptomatic , carcinoma in situ , bethesda system , carcinoma , gynecology , cancer
Background Although the incidence of glandular epithelial abnormalities on cervical cytology is low, the clinical and histologic findings are often significant. The laboratory's 12‐year experience is reported. Methods from January 1, 2003 to December 31, 2014, the Cytopathology Laboratory of the University of Wisconsin Hospital and Clinics processed 191,087 ThinPrep ® Pap Tests of which 184 (0.1%) were reported as glandular epithelial abnormalities. One hundred forty‐three (78%) of these cases had histologic follow‐up and form the basis of this study. Of the 143 women (mean age, 52; median, 50), 45% presented with vaginal bleeding and 55% were asymptomatic. The cytologic groups included atypical glandular cells, atypical glandular cells; favor a neoplastic process, atypical endocervical cells, atypical endocervical cells; favor a neoplastic process, endocervical adenocarcinoma in situ, atypical endometrial cells and adenocarcinoma, NOS. Results Overall, the histologic follow‐up showed epithelial abnormalities including endometrial and endocervical carcinoma, endocervical adenocarcinoma in situ, CIN 3 involving endocervical glands and metastatic carcinoma in 78% of the cases. The diagnoses were age‐dependent and influenced by clinical symptomatology. Conclusion Glandular epithelial abnormalities on Pap tests warrant further clinical investigation. Diagn. Cytopathol. 2016;44:389–393. © 2016 Wiley Periodicals, Inc.