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Is there a role for the thinprep imaging system in reporting anal cytology?
Author(s) -
Roberts Jennifer Margaret,
Jin Fengyi,
Ekman Deborah,
Adams Marjorie Kay,
McDonald Ross Lindsay,
Thurloe Julia Kathleen,
Richards Adele,
Poynten Isobel Mary,
Law Carmella,
Fairley Christopher Kincaid,
Hillman Richard John,
Tabrizi Sepehr N.,
Cornall Alyssa Marie,
Templeton David James,
Garland Suzanne Marie,
Grulich Andrew Edwin,
Farnsworth Annabelle
Publication year - 2016
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23451
Subject(s) - medicine , cytology , squamous intraepithelial lesion , bethesda system , biopsy , gynecology , anal cancer , abnormality , cervical intraepithelial neoplasia , obstetrics , cervical cancer , radiology , pathology , human papillomavirus , cancer , psychiatry
Background The ThinPrep Imaging System (TIS) is an accurate time‐saving method of reading cervical ThinPrep slides in screening programs. As anal and cervical cytology are morphologically similar, TIS can potentially be used for anal cytology. We assessed the performance of TIS on anal ThinPrep slides from homosexual men in a natural history study of human papillomavirus‐related anal abnormalities. Methods Four hundred nineteen anal cytology slides were processed by TIS and classified by a cytologist as either No further review (slide archived) or Manual review (slide requiring full manual screen). The results were compared with the original manual screening report for all slides and specifically for those screening episodes accompanied by a high‐grade squamous intraepithelial lesion (HSIL) on concurrent biopsy. Results One hundred seventy six of 419 (42.0%) slides were classified as No further review , with a trend of decreasing proportions as the degree of severity of the cytological abnormality increased. Thirteen (27.7%) slides with an original unsatisfactory report were classified as No further review . Eighty two (92.1%) of those with biopsy HSIL and cytological abnormality were classified for Manual review , including all 45 (100%) with cytological HSIL. Conclusion The cervical algorithm of TIS performed best on anal samples when HSIL was present both cytologically and histologically. The 27.7% unsatisfactory slides classified as No further review may indicate need for use of different criteria from cervical cytology. Because of the high prevalence of abnormalities, and hence the large proportion of slides needing manual review, the cytologist time‐saving would compare unfavorably with use of TIS in cervical screening. Diagn. Cytopathol. 2016;44:384–388. © 2016 Wiley Periodicals, Inc.