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Reliability of fine‐needle aspiration and ultrasound‐based characteristics of thyroid nodules for diagnosing malignancy in Iranian patients
Author(s) -
Akhavan Asghar,
Jafari Seyyed Mehrdad,
Khosravi Mohammad Hossein,
Khajehpour Hojjatollah,
KarimiSari Hamidreza
Publication year - 2016
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23430
Subject(s) - medicine , nodule (geology) , thyroid nodules , malignancy , radiology , calcification , biopsy , fine needle aspiration , gold standard (test) , thyroid , pathological , ultrasound , pathology , paleontology , biology
Background Sonography and fine‐needle aspiration biopsy (FNA‐B) have been approved as method of choice in diagnosis of malignant thyroid nodules. Unnecessary FNA‐B not only is invasive and costly but also results in second biopsy or unnecessary surgery. So we aimed to determine the specificity and sensitivity of sonography and FNA‐B, without sonography guidance, in diagnosis of malignant and benign thyroid nodules. Methods Patients with thyroid nodule referred to Baqiyatallah Hospital in 2014–2015 and candidates for surgical nodule resection were selected using simple random sampling method. Patients were evaluated by sonography and FNA. Sonographic characteristics of nodule were described. All patients underwent surgical resection and gross samples were sent for pathological evaluation, the gold standard for measuring the specificity and sensitivity of sonographic findings and FNA in diagnosis of malignant nodules. Results Ninety patients with the mean age of 45.95 ± 12.3 years were evaluated (17 male and 73 female). Comparing the patients with correct and incorrect sonography‐based diagnosis showed significant differences in nodule's width, area, calcification, border, and cervical lymphadenopathy ( P < 0.05). Comparing the patients with correct and incorrect FNA‐based diagnosis showed significant differences in patients' age and tall‐shape nodule ( P < 0.05). The diagnosis of sonographist had 56.25% sensitivity and 95.9% specificity, and the FNA‐based diagnosis had 81.25% sensitivity and 93.7% specificity. Conclusion Among sonography findings, width and area of nodule, calcification, and nodule border have significant effect on malignancy diagnosis. Also FNA is necessary in nodules with calcification, border irregularity, and less width and area, especially in younger patients. Diagn. Cytopathol. 2016;44:269–273. © 2016 Wiley Periodicals, Inc.