Premium
Cytohistology of papillary carcinoid and emerging concept of pulmonary neuroendocrine neoplasms
Author(s) -
Yang Grace C. H.
Publication year - 2016
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23376
Subject(s) - medicine , pathology , carcinoid tumors , neuroendocrine tumors , neuroendocrine cell , lung , carcinoid tumour , small cell lung carcinoma , cytology , large cell , carcinoma , neuroendocrine carcinoma , small cell carcinoma , immunohistochemistry , cancer , adenocarcinoma
This timely review starts by reporting the clinical, cytologic and histologic features of a morphologic variant of pulmonary carcinoid tumor forming exclusively of papillae. This growth pattern is so rare that it was not included in 2014 WHO classification of pulmonary neuroendocrine neoplasms. The current concept is reviewed, and example of spindle cell carcinoid, atypical carcinoid, large cell neuroendocrine carcinoma, and small cell carcinoma are illustrated with fine needle aspiration cytology, surgical and clinical follow‐up. Finally, the new findings in cell biology and molecular biology that led to the emerging concept that carcinoids and high‐grade neuroendocrine lung carcinomas are separate biological entities are reviewed and summarized in a tumorigenic module. Diagn. Cytopathol. 2016;44:52–60. © 2015 Wiley Periodicals, Inc.