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Metastatic medullary thyroid carcinoma to the breast in a patient with combined medullary and papillary carcinoma of thyroid—A case report
Author(s) -
Alath Preetha,
Shafi Ahmed Inamdar Naquib,
AlJassar Aisha,
Hussein Sundus,
Amir Thasneem,
AlWaheeb Salah,
AlAbdulghani Rana,
George Sara Shirly,
Kapila Kusum
Publication year - 2015
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23226
Subject(s) - medicine , calcitonin , pleomorphism (cytology) , medullary carcinoma , thyroid , medullary cavity , pathology , thyroglobulin , thyroid carcinoma , metastasis , population , carcinoma , oncology , cancer , immunohistochemistry , environmental health
We report the fine‐needle aspiration cytology of a case of medullary thyroid carcinoma (MTC) metastatic to the breast in a 66‐year old female within two years of diagnosis of the thyroid tumor. The aspirate of the breast metastases revealed a plasmacytoid population of cells in loose clusters and singly with mild to moderate pleomorphism. Nuclear groves and occasional intranuclear cytoplasmic inclusions were seen. The cells stained positive for calcitonin and negative for thyroglobulin. Use of immunocytochemical methods proved useful to diagnose metastasis which was essential in planning treatment. Cases of metastatic MTC to the breast diagnosed on fine‐needle aspirates reported in the literature are reviewed. Diagn. Cytopathol. 2015;43:343–348. © 2014 Wiley Periodicals, Inc.