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Ultrasound‐guided fine‐needle aspiration of a posterior neck dedifferentiated liposarcoma with MDM2 fluorescence in situ hybridization performed on a Pap‐stained smear
Author(s) -
Zreik Riyam,
Soyalp Krystal,
Ruiz Steve,
Ward Russell,
Dobin Sheila,
Chen Xiangbai,
Liu Lina,
Rao Arundhati
Publication year - 2015
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23200
Subject(s) - medicine , fluorescence in situ hybridization , liposarcoma , pathology , fine needle aspiration , head and neck , soft tissue , population , ultrasound , radiology , biopsy , sarcoma , surgery , biology , biochemistry , gene , chromosome , environmental health
Head and neck liposarcomas, while rare, tend to be subcutaneous and well‐differentiated. Dedifferentiated liposarcomas of the head and neck are exceedingly rare in the literature. We present a case of a dedifferentiated liposarcoma arising in the soft tissue of the posterior neck of an 86‐year‐old man and diagnosed by fine‐needle aspiration. Aspirate smears showed a dual population of atypical lipomatous and spindled cells. MDM2 (murine double minute 2) amplification was demonstrated on a Pap‐stained smear using fluorescence in situ hybridization (FISH). To the best of our knowledge, this is the first report of MDM2 FISH amplification in a liposarcoma performed on an aspirate smear. Diagn. Cytopathol. 2015;43:320–324. © 2014 Wiley Periodicals, Inc.