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Cytological characteristics of papillary thyroid carcinoma on LBC specimens, compared with conventional specimens
Author(s) -
Suzuki Ayana,
Hirokawa Mitsuyoshi,
Higuchi Miyoko,
Yamao Naoki,
Kuma Seiji,
Nakamura Hirotoshi,
Amino Nobuyuki,
Miyauchi Akira
Publication year - 2015
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23191
Subject(s) - pathology , medicine , eosinophilic , thyroid , columnar cell , thyroid carcinoma , cytology , epithelium
Background The cytological findings in conventional specimens (C‐S) and liquid‐based cytology specimens (LBC‐S) are not quite same. The aim of this article is to clarify the cytological findings of papillary thyroid carcinoma (PTC) characteristic of LBC‐S. Methods Out of 5,971 cases diagnosed in a single institution from March to September in 2012, 161 PTC cases with both C‐S and LBC‐S were reviewed. Additionally, we compared the findings with those in LBC‐S of 55 adenomatous or hyperplastic nodule (AN) and 21 follicular neoplasm (FN) cases. Results Compared to C‐S, the incidences of trabecular and hobnail patterns, collagenous stroma, naked capillaries, intercellular spaces, convoluted nuclei, eosinophilic nucleoli, and perinucleolar halo were increased. Pale nuclei were observed in only one of 161 PTC cases. Specificity of convoluted nuclei and perinucleolar halo were 97.4% and 96.1%, respectively. Conclusion Convoluted nuclei and perinucleolar halo might become a new indicator of PTC in LBC‐S. Contrarily, we should be aware that pale nuclei are rarely observed in LBC‐S. Diagn. Cytopathol. 2015;43:108–113. © 2014 Wiley Periodicals, Inc.