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Clear cell chondrosarcoma: Cytologic findings in six cases
Author(s) -
Jiang Xiaoyin Sara,
Pantanowitz Liron,
Bui Marilyn M.,
Esther Robert,
Budwit Debra,
Dodd Leslie G.
Publication year - 2014
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23043
Subject(s) - medicine , chondrosarcoma , pathology , lesion , clear cell , biopsy , cytology , cytopathology , radiology , immunohistochemistry
Clear cell chondrosarcoma (CCCS) is a rare variant of chondrosarcoma characterized, in most instances, by indolent behavior and a long interval to progression of disease. CCCS commonly occurs in adult individuals and has a proclivity for the epiphysis of long bones, although it has been reported in other sites. This lesion is difficult to diagnose preoperatively. Factors contributing to difficulty in recognizing this lesion include its relative scarcity as well as its tendency to be confused with other lesions on imaging studies. In the following, we report six cases of CCCS initially diagnosed by fine needle aspiration and/or touch preparations of needle biopsy samples. The cytologic features identified include large, plasmacytoid cells with foamy cytoplasm as well as extracellular chondroid type matrix material. Definitive diagnosis was made in each case by recognizing the “clear cell” nature of the tumor on cell block material. Diagn. Cytopathol 2014;42:784–791. © 2013 Wiley Periodicals, Inc.