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The value of expert review in prospective trials of automated assisted screening devices
Author(s) -
Renshaw Andrew A.,
Elsheikh Tarik M.
Publication year - 2014
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.23001
Subject(s) - medicine , ascus (bryozoa) , sensitivity (control systems) , expert opinion , value (mathematics) , prospective cohort study , medical physics , statistics , surgery , intensive care medicine , botany , ascospore , mathematics , spore , electronic engineering , engineering , biology
Previous prospective studies of automated assisted gynecologic screening devices have used a panel of experts for truth determination. We sought to determine the value of this practice. The relative sensitivity of the devices compared with manual screening was calculated using an expert panel for truth determination and compared using likelihood ratios to the relative sensitivity assuming all abnormal cases were truly abnormal. These results show that expert panel review has no significant effect on relative sensitivity at the threshold of ASCUS+ but may have an effect at HSIL+. Trials without expert consensus review may be compared to those with expert consensus review at the threshold of ASCUS+ but may not be reliable at the threshold of HSIL+ without additional confirmatory data. Diagn. Cytopathol. 2014;42: 117–119. © 2013 Wiley Periodicals, Inc.