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A case of anaplastic lymphoma kinase‐positive large B‐cell lymphoma: Aspiration cytology findings
Author(s) -
Nakatsuka Shinichi,
Oku Kazuko,
Nagano Teruaki,
Kimura Hayato,
Hanamoto Atsushi,
Ito Mahito,
Hashimoto Koji
Publication year - 2014
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.22968
Subject(s) - anaplastic lymphoma kinase , cd30 , pathology , lymphoma , anaplastic large cell lymphoma , lymph node , medicine , cytopathology , large cell lymphoma , cytokeratin , fluorescence in situ hybridization , immunohistochemistry , cytology , biology , biochemistry , gene , malignant pleural effusion , chromosome , lung cancer
Anaplastic lymphoma kinase‐positive (ALK+) large B‐cell lymphoma (LBCL) is a rare subtype of non‐Hodgkin B‐cell lymphoma that exhibits a more aggressive clinical course and poorer prognosis than the typical diffuse large B‐cell lymphoma. In this study, we report the case of a 67‐year‐old man with left cervical lymph node swelling. Aspiration cytology revealed many clusters of cohesive, large, and solitary cells. The tumor cells had abundant cytoplasm and large round‐to‐oval nuclei with prominent nucleoli. The Giemsa staining specimens exhibited amorphous global bodies adjacent to some clusters. Histologically, large tumor cells occupied the lymph nodes in a sinusoidal pattern, and immunohistochemically, these cells were cytokeratin−, CD19 − , CD20 − , CD79a − , CD3 − , CD30 − , CD138 + , IgG − , IgA + , and ALK + . Chromogenic in situ hybridization revealed restricted immunoglobulin light‐chain expression. Fluorescent in situ hybridization demonstrated translocation of the ALK gene. The tumor cells were negative for Epstein–Barr virus and human herpesvirus 8. It is important to differentiate ALK+LBCL from metastatic carcinoma and other lymphoma subtypes with similar histological features to ensure a proper treatment strategy and prediction of prognosis. Diagn. Cytopathol. 2014;42:69–72. © 2013 Wiley Periodicals, Inc.