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Cytoplasmic vacuolization: An under‐recognized cytomorphologic feature in endocrine tumors of the pancreas
Author(s) -
Levy Gillian H.,
Finkelstein Alexander,
Harigopal Malini,
Chhieng David,
Cai Guoping
Publication year - 2013
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.22893
Subject(s) - fine needle aspiration , medicine , pathology , pancreas , cytopathology , endocrine system , radiology , biopsy , cytology , hormone
Abstract The diagnosis of pancreatic endocrine neoplasm (PEN) is often straightforward; however, cytomorphologic variants may impose a diagnostic challenge, particularly in small biopsies such as fine‐needle aspiration (FNA). Here we describe prominent fine cytoplasmic vacuoles in three cases of PENs which were initially evaluated by endoscopic ultrasound‐guided FNA. The clinicopathologic features and diagnostic pitfalls of this cytomorphologic variant were discussed. Awareness of this rare cytomorphologic feature with application of immunocytochemical studies is crucial for rendering an accurate diagnosis and avoiding diagnostic pitfalls. Diagn. Cytopathol. 2013. © 2012 Wiley Periodicals, Inc.