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Cytomorphologic diagnosis and HPV testing of metastatic and primary oropharyngeal squamous cell carcinomas: A review and summary of the literature
Author(s) -
Jarboe Elke A.,
Hunt Jason P.,
Layfield Lester J.
Publication year - 2012
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.22837
Subject(s) - medicine , human papillomavirus , head and neck , cytopathology , fine needle aspiration , oncology , cytology , pathology , basal cell , radiology , biopsy , surgery
A significant proportion of squamous cell carcinomas (SCC) of the oropharynx are associated with high‐risk human papillomavirus (HPV). These HPV‐related carcinomas are prognostically and therapeutically different from traditional SCC of the head and neck. Cervical metastases from head and neck primary SCC are frequently investigated by fine‐needle aspiration (FNA). HPV testing of cytologic samples from these lesions would potentially simplify diagnosis and therapeutic planning. This review summarizes current methodologies for HPV testing of FNA specimens and the role of HPV typing in diagnosis, prediction of prognosis, and selection of therapy. Diagn. Cytopathol. 2012;40:491–497. © 2012 Wiley Periodicals, Inc.