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Smear cytology findings of large cell neuroendocrine carcinoma of the uterine cervix
Author(s) -
Kuroda Naoto,
Wada Yukari,
Inoue Kaori,
Ohara Masahiko,
Mizuno Keiko,
Toi Makoto,
Tanaka Azusa,
Wani Yoji,
Yanai Hiroyuki
Publication year - 2013
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21834
Subject(s) - medicine , pathology , neuroendocrine differentiation , cytology , carcinoma , cervix , synaptophysin , adenocarcinoma , immunohistochemistry , uterine cervix , endometrium , cancer , prostate cancer
Large cell neuroendocrine carcinoma (LCNEC) of the uterine cervix is a rare tumor. Moreover, there are only three reports to date that have focused on the cytologic findings of cervical LCNEC. We report the case of a 59‐year‐old Japanese woman with cervical LCNEC combined with small cell carcinoma (SmCC). Cytologic specimens from the uterine cervix demonstrated large cells with coarse chromatin and prominent nucleoli. Frequent mitotic figures were also observed. Curettage of the uterine endometrium revealed an endometrioid adenocarcinoma with squamous differentiation; i.e., an adenoacanthoma. Histologic examination of surgically resected uterine cervical tissue revealed LCNEC with minor foci of SmCC. Neuroendocrine differentiation in LCNEC was confirmed by immunohistochemistry for synaptophysin and CD56. Cytotechnologists or pathologists need to consider a differential diagnosis of LCNEC while examining cervical cytologic specimens; therefore, it is important to correctly identify the cytologic characteristics of this tumor. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc.