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Squamous cell carcinoma with rhabdoid phenotype of skin/soft tissue in a transplant patient: An exceptional case and review of the literature
Author(s) -
AllamNandyala Pushpa,
Bui Marilyn M.,
DeConti Ronald,
Purohit Chetna,
Altiok Soner
Publication year - 2013
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21788
Subject(s) - medicine , biopsy , fine needle aspiration , pathology , immunohistochemistry , basal cell , skin biopsy , phenotype , transplantation , differential diagnosis , forearm , soft tissue , dermatology , surgery , biology , biochemistry , gene
Abstract Squamous cell carcinoma with rhabdoid features (SCCRF) is a very rare and unusual cutaneous tumor. Here, we report an extraordinary case diagnosed by fine needle aspiration biopsy, in a 66‐year‐old man, status post multiple organ transplantation. The patient presented with a large ulcerating fungating mass in his forearm that had all the light microscopic and immunohistochemical features of a SCCRF. Previously six cases of SCCRF phenotype diagnosed by surgical pathology have been reported. This is the first case diagnosed cytologically. A review of the literature with emphasis on the differential diagnoses of such unusual rhabdoid‐like tumors in fine‐needle aspiration biopsy and the potential molecular mechanism for rhabdoid phenotype in transplant patients are discussed. Diagn. Cytopathol. 2013. © 2011 Wiley Periodicals, Inc