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Cytomorphology of giant cell glioblastoma: Report of a case and brief review of literature
Author(s) -
Jaiswal Sushila,
Vij Mukul,
Pandey Rakesh,
Jaiswal Awadhesh Kumar,
Srivastava Arun Kumar,
Behari Sanjay
Publication year - 2012
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21648
Subject(s) - giant cell , glioblastoma , medicine , pathology , differential diagnosis , population , glioma , cancer research , environmental health
Giant cell glioblastoma is a histological variant of glioblastoma that accounts for less than 1% of intracranial tumors and to 5% of glioblastoma. They occur at any age and are likely to affect the younger as well the older age group unlike the conventional glioblastoma multiforme (GBM). They are often located subcortically in the temporal and parietal lobes. Cytological descriptions of giant cell glioblastoma are extremely rare. We describe squash cytomorphology of giant cell glioblastoma of left posterior frontal region in 35‐year‐old male. The squash smears were moderately cellular displaying malignant astrocytic tumor cells disposed in cohesive clusters and dispersed population on a necrotic background. Most striking feature was numerous multinucleated giant cells. We also discuss the differential diagnosis in light of relevant literature. Diagn. Cytopathol.2012;40:440–443. © 2011 Wiley Periodicals, Inc.