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Male urethral pap smears and peniscopy examination and polymerase chain reaction human papillomavirus correlation
Author(s) -
Lilia TenaSuck Martha,
AlarcónHerrera América,
TiradoSánchez Andrés,
Rösl Frank,
la Vega Horacio Astudillode
Publication year - 2012
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21595
Subject(s) - medicine , koilocyte , population , polymerase chain reaction , penis , gynecology , chlamydia , pathology , cervical cancer , cancer , cervical intraepithelial neoplasia , surgery , biology , immunology , biochemistry , gene , environmental health
The aims of this study were to determine HPV in a male population and its correlation with penile gross inspection and urethral pap smears. Fifty male volunteers were included in the study; all of them were sexual partners of women with evidence of HPV‐related cervical diseases. Urethral Pap smear features and polymerase chain reaction (PCR; HPV detection) of urethral samples were correlated. Statistical analyses were conducted to identify variables associated with high and low‐risk HPV types. Mean age of participants was 33.14 ± 1.52 (range, 23–50 years), and the mean age for those with high risk HPV was 32.12 ± 6.66 and 34.08 ± 6.58 for subjects with low‐risk HPV ( P = 0.820). Penile gross inspection revealed 19 (38%) cases with no lesions, papules in balanoprepusial furrol/sulcus in 23 (46%) cases, papilla in 23 (46%) cases, urethral lesions in 22 (44%) cases, penile body plaques in 22 (44%) cases, melanoses in 11 (22%) cases, sebaceous cysts on scrotum in 10 (20%) cases, and molting of the glands in 28 (56%) cases. Cytopathologic analysis revealed koilocytes in 24 (48%) cases. Dyskeratosis was observed in 24 (48%) cases. A bacterial background was found in 27 (54%) cases, and inflammatory cells were found in 27 (54%) cases. Twenty‐six (52%) cases showed cytological features suggestive of Gardnerella Vaginalis . Twenty‐four (48%) cases were high‐risk HPV, and 26 (52%) were low‐risk HPV ( P = 0.037) as assessed by PCR‐based detection. There was a statistically significant difference between koilocytes and bacterial background with high‐risk human papillomavirus ( P = 0.001). Abnormal colposcopy examination detected lesions were sampled for cytology by Pap smears. Diagn. Cytopathol. 2012. © 2011 Wiley Periodicals, Inc.