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Atypical teratoid/rhabdoid tumor: Analysis of cytomorphologic features in CSF, focused on the differential diagnosis from mimickers
Author(s) -
Choi Junjeong,
Kim Hoguen,
Kim Se Hoon
Publication year - 2012
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21594
Subject(s) - atypical teratoid rhabdoid tumor , medicine , pathology , differential diagnosis , cytopathology , cytology , immunohistochemistry
Atypical teratoid and rhabdoid tumor (AT/RT) is a rare tumor with fatal clinical consequences, usually affecting young children. A significant portion of patients present with dissemination to cerebrobspinal fluid (CSF). However, a limited number of studies are available regarding the cytomorphologic findings of AT/RT in CSF. We collected eight cases of CSF cytology of AT/RT and describe the cytomorphologic features of AT/RT in CSF. Typical rhabdoid cells are found in most cases and they are characterized by eccentric nuclei, abundant cytoplasm, and clustering of the tumor cells. The presence of these cells in CSF indicates disseminated diseases and aggressive therapeutic consideration for patient management is required. Diagn. Cytopathol. 2010. © 2010 Wiley Periodicals, Inc.