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Cytological features of myxomatous fibroadenoma of the breast
Author(s) -
Yamaguchi Rin,
Tanaka Maki,
Yokoyama Toshiro,
aka Yasuhide,
Mizushima Yasuko,
Kawahara Akihiko,
Yoshida Tomoko,
Ito Tsutomu,
Yamaguchi Miki,
Kage Masayoshi,
Yano Hirohisa
Publication year - 2012
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21567
Subject(s) - medicine , malignancy , pathology , metachromasia , cytology , mucinous carcinoma , histology , exact test , carcinoma , fibroadenoma , staining , biopsy , gastroenterology , adenocarcinoma , cancer , breast cancer
Fibroadenoma (FA) is a benign tumor that must be differentiated from carcinomas. FAs often exhibit myxedematous changes (myxomatous FA, M‐FA). We previously reported on the clinical significance of M‐FA. M‐FA and (mucinous) carcinoma share clinical findings, rapid growth and a relatively large size, a high‐depth/width (D/W) ratio, a relatively round shape, and posterior echo enhancement with internal hyperechogenicity on ultrasonography (US). Next, a biopsy is required for differential diagnosis. In this study, we evaluated the diagnostic significance of the cytological findings of M‐FA with US findings. Among 13 FAs that were diagnosed by cytology, we compared (i) a group of six mucinous carcinomas with acellular mucin and a D/W ratio ≥ 0.7 (a suspicious factor for malignancy) with a group with a D/W ratio of <0.7, and (ii) the frequency of metachromasia on Giemsa stain between M‐FAs and non‐M‐FAs among eight FA cases confirmed by histology. (i) FA lesions (7 of 13) showed metachromasia with Giemsa staining significantly more frequently than did mucinous carcinoma (0/6) (Fisher's exact test, P < 0.044). FA lesions with a D/W ratio ≥ 0.7 (6/7) showed metachromasia significantly more frequently than did FA with a D/W ratio <0.7 (1/6) (Fisher's exact test, P < 0.029). Among eight FA cases confirmed by histology, M‐FA cases (6/6) demonstrated metachromasia significantly more frequently than non‐M‐FA cases (0/2) ( P < 0.036). M‐FA cytologically exhibits marked metachromasia on Giemsa staining. Combining cytological examination and understanding the clinical features of M‐FA may allow us to choose cytological examination as a first‐line diagnostic method for tumor‐forming lesions. Diagn. Cytopathol. 2011. © 2011 Wiley‐Liss, Inc.