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Myxoid liposarcoma: A case report of a sentinel metastasis to the parotid gland with molecular confirmation
Author(s) -
Been Laura,
Olar Adriana,
Powers Martin P.,
LópezTerrada Dolores,
Laucirica Rodolfo
Publication year - 2011
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21553
Subject(s) - myxoid liposarcoma , medicine , liposarcoma , pleomorphism (cytology) , parotid gland , cytopathology , fine needle aspiration , malignancy , pathology , biopsy , soft tissue , wide local excision , metastasis , lesion , sarcoma , cytology , cancer , immunohistochemistry
Myxoid liposarcoma is a subtype of liposarcoma with a predilection for the deep soft tissues of the extremities that accounts approximately for 10% of all adult soft tissue sarcomas. We report a case of a metastatic myxoid liposarcoma to the parotid gland, with fine‐needle aspiration cytology correlation and molecular characterization. The lesion was diagnosed in a 53‐year‐old Hispanic male who presented with a left posterior thigh mass. A core needle biopsy established the diagnosis of myxoid liposarcoma. The patient underwent limb‐sparing, wide local excision of the malignancy and later presented with an initial metastatic lesion to the parotid gland. The diagnosis of metastatic myxoid liposarcoma was rendered by fine‐needle aspiration cytology with cell block preparation, and molecular confirmation. Although myxoid/round cell liposarcomas are classically described as having minimal pleomorphism on cytologic material, we encountered significant pleomorphism in our case. Therefore, a diagnosis of myxoid/round cell liposarcoma should still be a diagnostic consideration even if markedly pleomorphic cells are seen in fine‐needle aspiration biopsies. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.