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Diagnostic utility of vitreous humor fluid cytology for intraocular sarcoidosis: A clinicopathologic study of 7 cases
Author(s) -
Kinoshita Yuichi,
Takasu Kosho,
Adachi Yasuhi,
Yuri Takashi,
Matsunaga Shiho,
Nagumo Sachiko,
Shikata Nobuaki
Publication year - 2012
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21540
Subject(s) - sarcoidosis , medicine , uveitis , cytology , vitrectomy , pathology , ophthalmology , dermatology , visual acuity
Abstract Sarcoidosis is an enigmatic multisystem sarcoid disease occurring mainly in the lungs, skin, and eyes. Sarcoidosis of the eyes (intraocular sarcoidosis) has been proposed as one of the causes of uveitis. We carried out a clinicopathological study involving seven patients with intraocular sarcoidosis based on vitreous humor fluid cytology. In the seven patients, the sex ratio was 4:3, and the average age at onset was 65.6‐years‐old. Vitreous opacity was noted in all patients and snowball‐like vitreous opacity in 85.7%. Nerve papilloedema was noted in 42.9%. Diagnostic vitrectomy and adrenocortical hormone therapy were performed in all patients. As a result, the symptoms were improved. Vitreous perfusion fluid cytology revealed multinucleate giant cells in 85.7% and lymphocytes and epithelioid cells in all cases. Cytological diagnosis is not included in the current criteria for sarcoidosis, but its value in the diagnosis of intraocular sarcoidosis was suggested based in present study. Diagn. Cytopathol. 2012. © 2010 Wiley Periodicals, Inc.