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Polyomavirus infection and urothelial carcinoma
Author(s) -
Loghavi Sanam,
Bose Shikha
Publication year - 2011
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21490
Subject(s) - medicine , pathology , polyomavirus infections , urine cytology , histology , papanicolaou stain , cytology , stain , cytopathology , population , biopsy , bk virus , staining , kidney , cystoscopy , cancer , cervical cancer , alternative medicine , environmental health , kidney transplantation
Abstract Introduction: Polyomavirus infections are common in the general (adult) population with a reported prevalence of more than 80%. Polyomavirus can infect urothelial carcinoma and change the morphology of these malignant cells, as is shown in this paper. Material and Methods: An eighty year old Hispanic male was referred to the urology clinic for diagnosis and treatment. The submitted voided urine sample was concentrated, processed, and a SurePath preparation was made. Results and Discussion: The Papanicolaou‐stained slides contained single cells with very large hyperchromatic nuclei with a glassy appearance in addition to atypical neoplastic cells. The single cells with enlarged nuclei proved to stain positive for Simian virus 40 (SV40) antigen. The nuclei of these cells were 2 to 4 times larger than that of the surrounding noninfected atypical cells. These findings were confirmed on histologic sections prepared from tissue biopsy. Conclusion: In conclusion we report that it is difficult to distinguish benign polyomavirus infected cells from their malignant counterparts in cytology but not in histology. Diagn. Cytopathol. 2010. © 2010 Wiley‐Liss, Inc.