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Malignant Leydig‐cell tumor of the testis diagnosed by fine‐needle aspiration using ThinPrep technique
Author(s) -
Valeri RosaliaMaria,
Kotakidou Rodoula,
Michalakis Konstantinos,
Andreadis Charalambos,
KousiKoliakou Kokkona,
Destouni Charikleia
Publication year - 2011
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21446
Subject(s) - medicine , fine needle aspiration , pathology , leydig cell tumor , atypia , gynecomastia , biopsy , nuclear atypia , cytology , malignancy , nucleolus , cytopathology , eosinophilic , leydig cell , immunohistochemistry , nucleus , psychiatry , hormone , luteinizing hormone
Leydig cell tumors (LCT) are rare sex cord‐stromal tumors that account for 2–3% of all testicular tumors. Approximately 10% of LCTs shows evidence of malignant behavior. We present a case of LCT with severe atypia diagnosed by fine‐needle aspiration (FNA) in a 49‐year‐old man who presented with gynecomastia and right testis enlargement. The FNA material on conventional and ThinPrep smears revealed a hemorrhagic and necrotic background with high cellularity, consisting of large cells, isolated or in small cohesive clusters, abundant, eosinophilic cytoplasm, round nuclei, fine chromatin, and variably conspicuous nucleoli. Occasionally, pleomorphic cells with hyperchromatic nuclei and prominent nucleoli were seen. Immunocytochemistry was positive against vimentin, inhibin, and calretinin. Histological examination of the surgical specimen was in accordance with the FNA findings. The cytologic diagnosis of LCT of the testis, using FNA, is achievable in a preoperative setting to vitiate the need for more invasive biopsy procedures; malignancy could be considered on cytology when necrosis and marked atypia are evident. Diagn. Cytopathol. 2011. © 2010 Wiley‐Liss, Inc.