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Fine‐needle aspiration biopsy of low‐grade cribriform cystadenocarcinoma of the salivary gland
Author(s) -
Nakazawa Tadao,
Kondo Tetsuo,
Yuminomochi Tsutomu,
Nakazawa Kumiko,
Ishii Yoshio,
Mochizuki Kunio,
Kawasaki Tomonori,
Yamane Tetsu,
Miyata Masanori,
Motosugi Utaroh,
Katoh, Ryohei
Publication year - 2011
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21405
Subject(s) - cribriform , medicine , pathology , malignancy , biopsy , fine needle aspiration , atypia , nuclear atypia , cytopathology , cystadenocarcinoma , ductal carcinoma , parotidectomy , salivary duct carcinoma , parotid gland , salivary gland , adenocarcinoma , immunohistochemistry , cytology , cancer , breast cancer
Abstract Low‐grade cribriform cystadenocarcinoma (LGCCC) is a rare tumor, defined in the 2005 WHO classification as a primary salivary duct tumor. Previously, the neoplasm had been recognized as a variant of salivary duct carcinomas. A 56‐year‐old Japanese woman noticed a mass in the left subaural region. On radiological examinations, a multicystic tumor was seen in the left parotid gland. Fine‐needle aspiration biopsy was performed. The smears revealed several characteristic cytologic features. The tumor cells were arranged in irregular overlapping and showed inconspicuous nuclear atypia with variable‐sized and irregularly shaped cytoplasmic vacuoles. Based on these findings, a cystic tumor with uncertain malignancy was diagnosed. A parotidectomy was performed, because the tumor was slowly growing and contained solid components on the radiological images. Based on the histologic findings, along with immunohistochemistry, LGCCC was diagnosed based on resemblance to breast low‐grade ductal carcinoma in situ and intraductal proliferation of tumor cells. This is the first report of the cytomorphological findings of LGCCC. Diagn. Cytopathol.2011;39:218–222. © 2010 Wiley‐Liss, Inc.