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Cytodiagnosis of secretory carcinoma of the breast: A report on two cases
Author(s) -
Jena Madhusmita,
Shariff Shameem
Publication year - 2010
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21342
Subject(s) - breast carcinoma , histology , medicine , pathology , cytoplasm , carcinoma , nuclear atypia , atypia , cytology , cytopathology , fine needle aspiration , immunohistochemistry , biopsy , breast cancer , biology , cancer , biochemistry
Secretory carcinoma of the breast is a rare (<1%) low grade breast carcinoma which shows distinct features at histology. Diagnosis of this carcinoma at fine needle aspiration cytology (FNAC) is difficult. Two cases of secretory carcinoma of the breast presenting as a breast mass, one in a 24‐year‐old female and the other in a 40‐year‐old female are reported, highlighting their appearance at FNAC. In both the cases the aspirates were cellular and consisted of clusters and single cells with uniform round nuclei showing minimal nuclear atypia. Most of the cells had moderate to abundant cytoplasm with prominent intracytoplasmic vacuoles. Many cells showed a plasmacytoid appearance and others were binucleate. A typical amphophilic bubbly cytoplasm of the tumor cells was observed. Both cases were confirmed as secretory carcinoma on histology. The differences in cell morphology at FNAC of secretory carcinoma of the breast from other breast carcinomas, and its utility of making a preoperative diagnosis are discussed. Diagn. Cytopathol. 2010;38:921–924. © 2010 Wiley‐Liss, Inc.