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Ancillary testing in liquid based cytology to distinguish cervical glandular neoplasia from tuboendometrial metaplasia in a young woman
Author(s) -
Narine Nadira,
Rana Durgesh N.,
McVey Rhona J.,
Fitzmaurice Richard
Publication year - 2010
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21336
Subject(s) - colposcopy , medicine , cytology , liquid based cytology , gynecology , cervical intraepithelial neoplasia , endocervix , cytological techniques , squamous metaplasia , cytopathology , cervical cancer , pathology , obstetrics , cervix , cancer , epithelium
A 33‐year old woman had a cervical sample taken at colposcopy clinic. Seven years prior to this, at the age of 26, she had had a cytological diagnosis of cervical glandular neoplasia (cytology descriptor indicated cells suspicious of endocervical neoplasia) and severe dyskaryosis. Confirmation and treatment were by LLETZ and knife cone, and, in keeping with England and Wales National Health Service guidelines, this woman was under follow‐up by the colposcopy clinic. Intervening cytological follow‐up included a number of negative cytological samples interspaced with one equivocal report. A recent repeat cytology which was rather cellular contained several hyperchromatic crowded cell groups (HCCG's). Careful examination revealed benign endometrial clusters, LUS, TEM and endocervical cells in strips showing pseudostratification and loss of polarity. Following an agar block, there was positive staining for p16 and Ki‐67 in the abnormal groups whilst the benign TEM cells stained positive for bcl‐2. Diagn. Cytopathol. 2010;38:828–832. © 2010 Wiley‐Liss, Inc.