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Osteoclast‐rich undifferentiated carcinoma of the urinary tract: Cytologic findings and literature review
Author(s) -
CastelinoPrabhu Shobha,
Ali Syed Z.
Publication year - 2010
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21218
Subject(s) - medicine , giant cell , osteoclast , cytology , pathology , carcinoma , urinary system , differential diagnosis , receptor
The association of urothelial carcinoma with osteoclast‐like giant cells is an exceptionally rare event. To our knowledge, there are no published reports of the cytopathologic characteristics of osteoclast‐rich undifferentiated carcinoma of the urinary tract. We report herein, the case of a 63‐year‐old man who was evaluated at The Johns Hopkins Hospital for gross hematuria of 4 months duration. Urinary cytology displayed high‐grade malignant cells with scattered osteoclast‐like giant cells in a background of acute inflammation and abundant red blood cells. Subsequently, a transurethral tumor resection was performed, which revealed infiltrating undifferentiated carcinoma with osteoclast‐like giant cells. The rarity of this neoplasm and its resemblance to other giant cell‐rich processes may pose diagnostic difficulties. A review of the important differential diagnoses is also presented. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.