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CD13+ anaplastic large cell lymphoma with leukemic presentation and additional chromosomal abnormality
Author(s) -
Ries Sunčica,
Rnjak Lana,
Mitrović Zdravko,
Kuveždić Koraljka Gjadrov,
Nola Marin,
Sučić Mirna
Publication year - 2010
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21170
Subject(s) - anaplastic large cell lymphoma , medicine , myeloid , lymphoma , large cell lymphoma , pathology , large cell , abnormality , anaplastic lymphoma kinase , bone marrow , neoplasm , histiocyte , differential diagnosis , cancer , cancer research , adenocarcinoma , psychiatry , malignant pleural effusion , lung cancer
Anaplastic large cell lymphoma (ALCL) is a highly malignant neoplasm characterized by pleomorphic appearance, different immunophenotypes and variable sites of involvement. Expression of myeloid‐associated markers in anaplastic large cell lymphomas may mislead the medical team and result in delay of diagnosis due to unusual phenotype. It is important to diagnose this type of tumors and distinguish it from myeloid neoplasms (extramedullary myeloid cell tumors and histiocytic tumors) since therapy and prognosis are significantly different. A 16‐year‐old female patient presented with fever, lymphadenopathy, and high white blood cell count. Diagnosing a CD13+ ALCL with leukemic presentation with additional cytogenetic abnormality (duplication 5q35) was a significant diagnostic challenge. This combination of features, unusual for lymphoma, should be considered in differential diagnosis of myeloid neoplasms and fatal infections. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.