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Tumoral calcium pyrophosphate dihydrate crystal deposition disease: A rare diagnosis by fine‐needle aspiration
Author(s) -
Kishore B.,
Khare P.,
Gupta R. Jain,
Gupta C.,
Khare V.
Publication year - 2010
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21155
Subject(s) - medicine , fine needle aspiration , calcium pyrophosphate , pyrophosphate , calcium , rare disease , pathology , disease , biopsy , biochemistry , chemistry , enzyme
Calcium pyrophosphate dihydrate crystal deposition disease (CPPD) is a well‐recognized inflammatory joint disorder characterized by presence of calcium pyrophosphate dihydrate crystals in intraarticular and periarticular tissue. We report here a case of a 48‐year‐old male who presented with painless right hand swelling. Clinical suspicion was that of malignant soft tissue tumor. Fine‐needle aspiration (FNA) yielded chalky white gritty material. Microscopic examination showed large areas of basophilic calcified material, histiocytes, giant cells and characteristic rhomboid shaped crystals. At places, chondroid material was also identified, hence, diagnosis of CPPD was made. This was confirmed on histopathological examination. Tophaceous/ tumoral pseudogout is a rare form of CPPD and it is important to recognize that this form can be diagnosed in FNA cytology (FNAC) and misdiagnosis of benign or malignant cartilaginous lesions can be avoided. Diagn. Cytopathol. 2010. © 2009 Wiley‐Liss, Inc.