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Cell survival and apoptosis‐related molecules in cancer cells in effusions: A comprehensive review
Author(s) -
Kleinberg Lilach,
Davidson Ben
Publication year - 2009
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.21095
Subject(s) - medicine , apoptosis , cancer research , cancer , cancer cell , programmed cell death , microbiology and biotechnology , genetics , biology
Spreading of cancer cells to effusions is a manifestation of advanced disease, for which the chances of achieving cure using conventional treatment are low. This emphasizes both the importance of improving early detection and the need for developing targeted therapy modes. Such approaches should be based on characterization of the antiapoptotic, survival and drug resistance mechanisms of the metastatic cells in addition to analysis of the primary tumor. This review presents current knowledge regarding the expression and clinical role of cell survival and apoptosis‐related molecules in nonhematological cancers in effusions. Differences in the anatomic site‐related expression and clinical role of these proteins are additionally discussed. The data presented highlight the complexity of the multiple molecular pathways that mediate tumor cell survival within the serosal cavities. Diagn. Cytopathol. 2009. © 2009 Wiley‐Liss, Inc.