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Multinucleated giant cells in HIV‐associated benign lymphoepithelial cyst‐like lesions of the parotid gland on FNAC
Author(s) -
Gupta Nalini,
Gupta Ruchi,
Rajwanshi Arvind,
Bakshi Jaimanti
Publication year - 2009
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20991
Subject(s) - giant cell , pathology , histiocyte , multinucleate , medicine , lymphoid hyperplasia , parotid gland , lesion , germinal center , cyst , lumen (anatomy) , anatomy , lymphoma , b cell , antibody , immunology , surgery
Benign lymphoepithelial cyst‐like lesion (BLEL), a previously rare lesion of the parotid gland consisting of marked lymphoid hyperplasia with accompanying squamous‐lined cysts, has been described in patients with the acquired immune deficiency syndrome (AIDS) or AIDS risk factors. Histologically, these cysts are lined by a squamous or cuboidal epithelium. The lumen contains a pale homogenous material with foamy macrophages and lymphocytes with the cyst wall having germinal centers and a dense infiltrate of lymphoid cells. On FNAC, the aspirates are mostly cystic with the presence of reactive lymphoid tissue, numerous histiocytes, and metaplastic cell clusters. Multinucleated giant cells (MGCs) are also rarely seen in such lesions. We report a case of HIV‐associated BLEL with numerous large sized multinucleated giant cells. Diagn. Cytopathol. 2009. © 2009 Wiley‐Liss, Inc.