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Cytologic diagnosis of metastatic seminoma to the prostate and urinary bladder: A case report
Author(s) -
Alsharif Mariam,
Aslan Deniz L.,
Jessurun Jose,
Gulbahce H. Evin,
Pambuccian Stefan E.
Publication year - 2008
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20881
Subject(s) - medicine , seminoma , prostate , urology , pathology , urine cytology , urinary bladder , lymph node , cytology , urinary system , radiology , chemotherapy , cystoscopy , cancer
A 42‐year‐old man presented with severe abdominal pain, constipation, and hematuria. The patient had a history of seminoma treated by chemotherapy followed by bilateral orchiectomy and retroperitoneal lymph node dissection 16 years earlier. A computed tomography (CT) scan showed a 8.0 × 6.0 × 5.0 cm mass in the retrovesical space, encompassing the left side of his proximal bladder, the prostate, and the rectum. A urine cytologic specimen showed loosely cohesive cell clusters composed of highly atypical large cells and occasional large, single cells with macronucleoli present in a background of mainly lymphocytes and histiocytes was diagnosed as recurrent seminoma. Prostate biopsies showed extensively necrotic seminoma with accompanying granulomatous reaction. The tumor cells were immunoreactive for c‐kit (CD117), placental‐like alkaline phosphatase (PLAP), D2‐40, and OCT4. To our knowledge, this is the second report on urine cytology of metastatic seminoma. Diagn. Cytopathol. 2008;36:734–738. © 2008 Wiley‐Liss, Inc.