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Cytomorphology of lymphoepithelioma‐like carcinoma of the urinary bladder: Report of two cases
Author(s) -
Cai Guoping,
Parwani Anil V.
Publication year - 2008
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20853
Subject(s) - lymphoepithelioma like carcinoma , pathology , medicine , urine cytology , differential diagnosis , lymphoepithelioma , urinary bladder , nucleolus , carcinoma , cytology , cystoscopy , urology , nasopharyngeal carcinoma , radiology , radiation therapy , virus , epstein–barr virus , alternative medicine , nucleus , virology , psychiatry
Lymphoepithelioma‐like carcinoma (LELC) of the urinary bladder is a rare variant of high‐grade urothelial carcinoma. Here, we report urine cytologic findings in two cases of this rare entity, the diagnosis of which was confirmed by histopathological examination of the resected tumors. The cytomorphologic features included large tumor cells with high nuclear to cytoplasmic ratios, vesicular chromatin, and prominent nucleoli, presented as single cells or intermixed with inflammatory cells. The differential diagnosis included otherwise typical high‐grade urothelial carcinoma, reactive urothelial cells and rarely large cell lymphoma. The rarity of the tumor cells may impose a diagnostic challenge in urine specimen. Diagn. Cytopathol. 2008; 36: 600–603. © 2008 Wiley‐Liss, Inc.