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Absence of microfollicular basement membrane: A new indicator in the diagnosis of follicular carcinoma thyroid
Author(s) -
Sahoo Maheswar,
Sekhri Tarun,
Tripathi Madhabi,
Rautela N.,
Solanki Y.
Publication year - 2008
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20833
Subject(s) - follicular phase , follicular carcinoma , medicine , follicle , stain , pathology , basement membrane , thyroid carcinoma , thyroid , carcinoma , cytology , staining , papillary carcinoma
The thyroid follicles represent a biological continuum. Each follicle is closely related to the follicle that is next to it. The important feature of a follicular carcinoma is a microfollicular pattern. We report a case of follicular carcinoma in a 48‐year‐old female that demonstrates microfollicles which are larger in size and contain more number of follicular cells in cytologic smears (20–29 cells) in contrary to the literature definition of microfollicles containing approximately 6–12 cells. We also demonstrate absence of basement membranes in these microfollicles in histologic sections by Silver Methanamine Stain, which may be an indicator to search for vascular and capsular invasion. This case report also describes postoperative positron emission tomography scan findings. Diagn. Cytopathol. 2008;36:519–522. © 2008 Wiley‐Liss, Inc.