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Cytology of metastatic prostate cancer following orchiectomy and antiandrogen therapy: A diagnostic challenge
Author(s) -
Rapkiewicz Amy,
Gorokhovsky Rimma,
Farcon Eduardo,
Das Kasturi
Publication year - 2008
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20814
Subject(s) - medicine , prostate cancer , androgen deprivation therapy , orchiectomy , prostate , adenocarcinoma , antiandrogen , androgen , oncology , urology , hormonal therapy , cancer , pathology , hormone
Androgen deprivation therapy induces apoptosis and decreases both cell proliferation and angiogenesis in prostate adenocarcinoma. The molecular alterations following androgen ablation translate into unique cytologic features in both primary and metastatic prostate adenocarcinoma. We describe the cytologic appearance of metastatic prostate carcinoma following both surgical castration and androgen deprivation therapy. Diagn. Cytopathol. 2008;36:499–502. © 2008 Wiley‐Liss, Inc.