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How accurate is cytological diagnosis of cervical glandular lesions?
Author(s) -
Moreira Marise A. R.,
Longatto Filho Adhemar,
Castelo Adauto,
de Barros Maria Rita Evangelista,
Silva Ana Paula da,
Thomann Patrícia,
Mattosinho de Castro Ferraz Maria da Gloria,
Dores Gerson Botacini das
Publication year - 2008
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20799
Subject(s) - medicine , cytology , liquid based cytology , bethesda system , cytological techniques , radiology , pathology , cervical cancer , cancer
Gynecological cytology has some inaccurate morphological categorization and poor interobserver reproducibility especially for glandular lesions. Liquid‐based cytology (LBC) preparations are presumed to reduce artifacts that interfere in diagnosis performance, but its value to correctly identify glandular alterations has not been sufficiently reported. The objective of this study was to compare the diagnostic performance and interobserver agreement of LBC and conventional Pap smear to identify histologically confirmed glandular lesions according to five cytologists. Sensitivity ranged from 55.8 to 73.1% and 32.7 to 48.1% for Pap smear and LBC, respectively. Specificity ranged from 66.1 to 87.1% and 69.4 to 94.4%, respectively. In general, agreement between pairs of cytologists was poor with κ‐values around 0.45. In conclusion, relying entirely on cervical cytology to rule out glandular lesions may be risky. The use of HPV DNA test alone or combined to screening glandular lesions may contribute to minimize the limitations of both conventional and LBC preparations to diagnose glandular abnormalities. Diagn. Cytopathol. 2008;36:270–274. © 2008 Wiley‐Liss, Inc.