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Endoscopic ultrasound‐guided fine‐needle aspiration of undifferentiated carcinoma with osteoclast‐like giant cells of the pancreas: A report of 2 cases with literature review
Author(s) -
Chopra Shefali,
Wu Mark LiCheng,
Imagawa David K.,
Lee John,
Gu Mai
Publication year - 2007
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20711
Subject(s) - giant cell , pathology , osteoclast , medicine , cytopathology , fine needle aspiration , basophilic , adenocarcinoma , biopsy , cytology , cancer , receptor
Undifferentiated carcinoma with osteoclast‐like giant cells of the pancreas is rare. Histologically it mimics the giant cell tumor of the bone and may be associated with a ductal adenocarcinoma. We recently encountered two such cases, both of which were biopsied by EUS‐guided FNA. Abundant multinucleated osteoclast‐like giant cells and many uniform mononuclear cells were present in case 1 so that the diagnosis was made. In case 2, many mononuclear tumor cells with vacuolated and basophilic cytoplasm were present, and rare osteoclast‐like giant cells were seen. A diagnosis of adenocarcinoma was made. In both cases, no conspicuous nuclear pleomorphism was noted in the mononuclear cells or the multinucleated giant cells. The histology of case 2 revealed a pure undifferentiated carcinoma with osteoclast‐like giant cells. In addition, a liver biopsy revealed globular amyloidosis. To our knowledge, this is the first report of pancreatic undifferentiated carcinoma with osteoclast‐like giant cells sampled by EUS‐guided FNA and the first case of hepatic globular amyloidosis associated with this tumor. Diagn. Cytopathol. 2007;35:601‐606. © 2007 Wiley‐Liss, Inc.