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Cytopathologic findings in “POEMS” syndrome associated with Castleman disease
Author(s) -
Owens Christopher L.,
Weir Edward G.,
Ali Syed Z.
Publication year - 2007
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20687
Subject(s) - medicine , poems syndrome , lymph node , pathology , lesion , castleman disease , plasmacytoma , population , polyneuropathy , disease , multiple myeloma , environmental health
A 34‐year‐old man with a history of a scorpion bite followed by increasing polyneuropathy and IgG lambda monoclonal gammopathy was referred for fine‐needle aspiration of a lytic bone lesion and an enlarged axillary lymph node. The findings in the bone lesion were consistent with a plasmacytoma. The FNA of the lymph node showed a peculiar capillary proliferation in a background of polymorphous mature lymphocytes. Flow cytometric analysis showed a mixed lymphoid population. The lymph node was originally signed out descriptively, but review of the case showed features consistent with Castleman disease. After the pathologic findings and clinical features were discussed with the clinical team, the diagnosis of POEMS syndrome was established. Subsequent surgical excision of the lymph node was diagnosed as hyaline vascular‐variant Castleman disease. Diagn. Cytopathol. 2007;35:512–515. © 2007 Wiley‐Liss, Inc.