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Desmoplastic small round cell tumor: Using FISH as an ancillary technique to support cytologic diagnosis in an unusual case
Author(s) -
Waugh Michael S.,
Dash Rajesh C.,
Turner Kristi C.,
Dodd Leslie G.
Publication year - 2007
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20669
Subject(s) - desmoplastic small round cell tumor , fluorescence in situ hybridization , immunohistochemistry , fish <actinopterygii> , medicine , pathology , cytology , chromosomal translocation , sarcoma , fusion gene , neoplasm , gene , biology , genetics , fishery , chromosome
Desmoplastic small round cell tumor is a rare and aggressive neoplasm that predominantly affects young males. In almost all cases, a reciprocal translocation is present resulting in the fusion of the Ewing sarcoma gene with the Wilms' tumor gene. Here we describe an unusual case occurring in a 59‐year‐old male, in which fluorescence in situ hybridization (FISH) was used in conjunction with immunohistochemical studies to confirm the diagnosis. To our knowledge, this is the first reported case of using FISH as an ancillary technique to confirm the cytologic diagnosis of this tumor. Diagn. Cytopathol. 2007;35:516–520. © 2007 Wiley‐Liss, Inc.