Premium
Liquid‐based endometrial cytology in the management of sonographically thickened endometrium
Author(s) -
Buccoliero Anna M.,
Gheri Chiara F.,
Castiglione Francesca,
Garbini Francesca,
Fambrini Massimiliano,
Bargelli Gianni,
Barbetti Alfredo,
Pappalardo Salvatore,
Taddei Antonio,
Boddi Vieri,
Scarselli Gian F.,
Marchionni Mauro,
Taddei Gian L.
Publication year - 2007
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20655
Subject(s) - medicine , cytology , endometrium , biopsy , gynecology , liquid based cytology , diagnostic accuracy , radiology , pathology , obstetrics , cancer , cervical cancer
Liquid‐based cytology represents an opportunity to re‐evaluate endometrial cytology. We evaluated the accuracy of liquid‐based endometrial cytology as compared to biopsy in 670 women scheduled for histeroscopy because of thickened endometrium (>4 mm), as evaluated by transvaginal sonography. Endometrial biopsy detected pathology in 41 (6%) of cases (21 of which were adenocarcinomas). Cytologic study found pathology in 62 (9%) cases (19 of which were adenocarcinomas). Two hundred ninety‐one biopsies (43%) and 28 (4%) cytologies were inadequate. The sensitivity and the specificity were estimated, respectively, at 95% and 98%; the positive and negative predictive values were estimated, respectively, at 83% and 99%. Cytology provided sufficient material more often than biopsy (P < 0.01). We consider endometrial cytology an efficacious diagnostic opportunity. It could be usefully applied in association with transvaginal sonography. The combination of these procedures might reduce more invasive and expensive diagnostic procedures. Diagn. Cytopathol. 2007;35:398–402. © 2007 Wiley‐Liss, Inc.