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Primary Ewing sarcoma/PNET of the kidney: Fine‐needle aspiration, histology, and dual color break apart FISH Assay
Author(s) -
Kang Steven H.,
Perle Mary Ann,
aka Daisuke,
Zhu Hongfa,
Chan Wai,
Yang Grace C. H.
Publication year - 2007
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20642
Subject(s) - medicine , ewing's sarcoma , sarcoma , pathology , cd99 , clear cell sarcoma , nephrectomy , biopsy , histology , vimentin , fluorescence in situ hybridization , fine needle aspiration , skull , anatomy , rib cage , kidney , biology , chromosome , immunohistochemistry , biochemistry , gene , endocrinology
A 34‐year‐old previously healthy Hispanic man presented with lower back pain. CT scan revealed an 8‐cm space‐occupying lesion in the superior pole of the left kidney with numerous small lytic lesions in the skull, vertebrae, ribs, and pelvic bones. CT‐guided fine‐needle aspiration biopsy revealed a high‐grade primitive small round cell tumor with the tumor cells being strongly positive for CD99 and vimentin. The patient subsequently underwent a left nephrectomy. Fluorescence in situ hybridization analysis using a DNA probe for the Ewing Sarcoma breakpoint region 1 (EWSR1) on chromosome 22g12 revealed a rearrangement of the EWSR1 locus. The diagnosis of primary Ewing sarcoma/primitive neuroectodermal tumor of the kidney was established. Diagn. Cytopathol. 2007;35:353–357. © 2007 Wiley‐Liss, Inc.