Premium
Well‐differentiated fetal adenocarcinoma of the lung: Cytomorphologic features on fine‐needle aspiration with emphasis on use of β‐catenin as a useful diagnostic marker
Author(s) -
Proctor Lori,
Folpe Andrew L.,
Esper Annette,
Wolfenden Linda L.,
Force Seth,
Logani Sanjay
Publication year - 2007
Publication title -
diagnostic cytopathology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.417
H-Index - 65
eISSN - 1097-0339
pISSN - 8755-1039
DOI - 10.1002/dc.20583
Subject(s) - medicine , adenocarcinoma , pathology , lung , fine needle aspiration , fetus , catenin , wnt signaling pathway , cancer , gene , biology , biopsy , pregnancy , biochemistry , genetics
Well‐differentiated fetal adenocarcinoma (WDFA), also known as low grade adenocarcinoma of the fetal lung type, is a rare pulmonary neoplasm now considered to be a variant of lung adenocarcinoma rather than a type of pulmonary blastoma. Upregulation of the Wnt signaling pathway with subsequent aberrant nuclear/cytoplasmic β‐catenin expression has been recently described in these tumors providing a possible pathogenetic role for this gene in WDFA. We describe the cytomorphologic findings of a case of WDFA in a 36‐yr‐old female patient and emphasize the diagnostic utility of aberrant nuclear/cytoplasmic expression of β‐catenin as an adjunct to the correct preoperative recognition of this tumor on aspiration cytology. Diagn. Cytopathol. 2007;35:39–42. © 2006 Wiley‐Liss, Inc.